Terreni L, De Simoni M G
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Neuroimmunomodulation. 1998 May-Aug;5(3-4):214-9. doi: 10.1159/000026339.
High levels of interleukin 6 (IL-6) have been found in the brain tissue or cerebrospinal fluid (CSF) in several CNS disorders including Alzheimer's disease, AIDS dementia complex, multiple sclerois, stroke, Parkinson's disease, traumatic brain injuries, brain tumors and CNS infections. In these diseases, IL-6 is also found in blood showing that CNS conditions can elicit a peripheral immune response. A direct secretion of IL-6 from brain to blood has been shown to be a major mechanism by which the brain activates peripheral metabolic, endocrine and immune responses. However, this communication is not straightforward and other regulatory mechanisms are likely to be there. Several lines of evidence obtained in the laboratory have shown that the brain significantly modulates IL-6 production in the periphery. Evidence will be given that: (i) central inflammatory stimuli efficiently induce peripheral IL-6; (ii) central opioids are effective modulators of peripheral IL-6, and (iii) the sympathetic nervous system represents an inhibitory pathway to peripheral IL-6.
在包括阿尔茨海默病、艾滋病痴呆综合征、多发性硬化症、中风、帕金森病、创伤性脑损伤、脑肿瘤和中枢神经系统感染在内的几种中枢神经系统疾病的脑组织或脑脊液（CSF）中，已发现高水平的白细胞介素6（IL-6）。在这些疾病中，血液中也发现了IL-6，这表明中枢神经系统疾病可引发外周免疫反应。大脑向血液中直接分泌IL-6已被证明是大脑激活外周代谢、内分泌和免疫反应的主要机制。然而，这种交流并非直接进行，可能还存在其他调节机制。实验室获得的几条证据表明，大脑能显著调节外周IL-6的产生。将给出以下证据：（i）中枢炎症刺激可有效诱导外周IL-6；（ii）中枢阿片类物质是外周IL-6的有效调节剂；（iii）交感神经系统是外周IL-6的一条抑制途径。
