抗惊厥单药治疗期间白细胞外周苯二氮䓬受体表达与中性粒细胞功能

Peripheral benzodiazepine receptor expression on leukocytes and neutrophil function during anticonvulsant monotherapy.

作者信息

Caldiroli E, Marino F, Cosentino M, De Ponti F, Fietta A M, Mazzone A, Zibetti A, Lecchini S, Frigo G M

机构信息

Department of Internal Medicine and Therapeutics, University of Pavia, Pavia and Varese, Italy.

出版信息

Pharmacology. 1998 Oct;57(4):215-21. doi: 10.1159/000028244.

DOI:10.1159/000028244

PMID:9730779

Abstract

Epileptic patients on long-term therapy with a single anticonvulsant showed enhanced expression of peripheral benzodiazepine receptors (pBZrs) on neutrophils, monocytes and lymphocytes. N-Formyl-methionyl-leucyl-phenylalanine-induced chemotaxis was significantly impaired in neutrophils from patients on carbamazepine (p < 0.01 vs. controls). Neutrophils from patients on phenytoin had enhanced phorbol myristate acetate-stimulated O-2 production (p < 0. 01 vs. controls) and neutrophils from patients on valproic acid had impaired phagocytosis frequency and Staphylococcus aureus lethality index (p < 0.01 vs. controls). Overexpression of pBZrs on leukocytes may reflect the clinical response to anticonvulsants and may play a role in the immunological effects of some of these drugs.

摘要

长期使用单一抗惊厥药治疗的癫痫患者，其嗜中性粒细胞、单核细胞和淋巴细胞上的外周苯二氮䓬受体（pBZrs）表达增强。卡马西平治疗患者的嗜中性粒细胞中，N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸诱导的趋化性显著受损（与对照组相比，p < 0.01）。苯妥英治疗患者的嗜中性粒细胞中，佛波酯肉豆蔻酸酯刺激的超氧阴离子生成增强（与对照组相比，p < 0.01），丙戊酸治疗患者的嗜中性粒细胞吞噬频率和金黄色葡萄球菌致死率指数受损（与对照组相比，p < 0.01）。白细胞上pBZrs的过表达可能反映了对抗惊厥药的临床反应，并且可能在其中一些药物的免疫效应中起作用。