实验性肿瘤转移中的内分泌影响。III. 甲状腺状态对睾丸内移植的256号Walker癌肉瘤转移及肿瘤细胞体外增殖的影响。
Endocrine implications in experimental tumoral metastasis. III. The influence of the thyroid status on the metastasis of 256 Walker carcinosarcoma intratesticularly grafted and on the in vitro proliferation of the tumoral cells.
作者信息
Zimel A, Zimel H, Ghinea E
出版信息
Endocrinologie. 1976 Jul-Sep;14(3):197-202.
The influence of thyroid status modifications on the metastasis of 256 Walker carcinosarcoma intratesticularly grafted to rats was examined. Inhibition of metastasization and of the secondary tumoral growth was noticed in animals chronically treated with thyroxine, while hypothyroidization realized either by surgery or by administration of synthetical antithyroid drugs enhanced metastasization and growth of the secondary tumors. The primary tumoral development was not significantly influenced by the thyroid status modifications. The variations of the thyroid hormonal level influenced nonspecifically the proliferation of the in vitro cultivated tumoral cells.
研究了甲状腺状态改变对移植到大鼠睾丸内的256株Walker癌肉瘤转移的影响。在用甲状腺素长期治疗的动物中，观察到转移和继发性肿瘤生长受到抑制，而通过手术或给予合成抗甲状腺药物实现的甲状腺功能减退则增强了继发性肿瘤的转移和生长。原发性肿瘤的发展未受到甲状腺状态改变的显著影响。甲状腺激素水平的变化非特异性地影响体外培养的肿瘤细胞的增殖。
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