士的宁的亚慢性膳食毒性：北美鹑比绿头鸭更不敏感。

Subchronic dietary toxicity of strychnine: bobwhite quail are less sensitive than mallard ducks.

作者信息

Sterner R T, Pedersen C A, Helsten B R, Goodall M J

机构信息

U.S. Department of Agriculture, National Wildlife Research Center, 1716 Heath Parkway, Ft. Collins, Colorado 80524-2719, USA.

出版信息

Arch Environ Contam Toxicol. 1998 Oct;35(3):498-505. doi: 10.1007/s002449900408.

DOI:10.1007/s002449900408

PMID:9732483

Abstract

Separate, 28-day, subchronic studies of strychnine dietary toxicity were conducted using northern bobwhite quail (Colinus virginianus) and mallard ducks (Anas platyrhynchos). Five groups (five males five females/group) of 29-week-old quail were fed Purina(R) Game Bird Breeder Layena(R) diets containing mean (+/-SD) 484.2 (+/-17.0), 972. 6 (+/-54.0), 1,870.8 (+/-176.1), 3,516.7 (+/-68.0), and 6,083.3 (+/-269.6) microgram/g strychnine; whereas five groups of 27-week-old mallards (five males five females/group) were fed similar diets containing mean (+/-SD) 18.8 (+/-1.3), 91.1 (+/-27.3), 235.0 (+/-33. 8), 484.2 (+/-17.0), and 972.6 (+/-54.0) microgram/g strychnine. Separate "vehicle control" (0.0 microgram/g strychnine) groups (five males, five females/group) were included in each study. Strychnine toxicity was much less pronounced in quail; no observed effect concentrations (NOECs) were 972.6 (+/-54.0) and 91.1 (+/-27.3) microgram/g strychnine for quail and ducks, respectively. Several possible explanations for the species effects are offered, and some practical issues affecting the conduct of long-term, dietary toxicity studies are discussed.

摘要

使用北部 Bobwhite 鹌鹑（Colinus virginianus）和绿头鸭（Anas platyrhynchos）进行了士的宁膳食毒性的单独的 28 天亚慢性研究。将五组（每组五只雄性和五只雌性）29 周龄的鹌鹑喂食含有平均（±标准差）484.2（±17.0）、972.6（±54.0）、1,870.8（±176.1）、3,516.7（±68.0）和 6,083.3（±269.6）微克/克士的宁的普瑞纳（Purina）牌猎鸟繁殖者莱耶纳（Layena）日粮；而五组 27 周龄的绿头鸭（每组五只雄性和五只雌性）则喂食含有平均（±标准差）18.8（±1.3）、91.1（±27.3）、235.0（±33.8）、484.2（±17.0）和 972.6（±54.0）微克/克士的宁的类似日粮。每项研究都包括单独的“溶剂对照”（0.0 微克/克士的宁）组（每组五只雄性和五只雌性）。士的宁对鹌鹑的毒性明显较小；鹌鹑和鸭子的未观察到效应浓度（NOECs）分别为 972.6（±54.0）和 91.1（±27.3）微克/克士的宁。文中提供了几种对物种效应的可能解释，并讨论了影响长期膳食毒性研究开展的一些实际问题。