Santos R M, Tanguay J F, Crowley J J, Kruse K R, Sanders-Millare D, Zidar J P, Phillips H R, Merhi Y, Garcia-Cantu E, Bonan R, Côté G, Stack R S
Duke University Medical Center, Durham, North Carolina 27710, USA.
Am J Cardiol. 1998 Sep 1;82(5):673-5, A8. doi: 10.1016/s0002-9149(98)00418-4.
We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.
在犬冠状动脉模型中，我们比较了通过药物洗脱支架局部给药的糖蛋白IIb/IIIa受体拮抗剂L-703,081与标准金属支架对血小板沉积的影响。与裸金属支架相比，使用L-703,081浸渍支架时血小板沉积显著减少。这项研究证明了糖蛋白IIb/IIIa拮抗剂的一种替代给药途径，其具有优于全身给药的潜在优势。
