母体输注促肾上腺皮质激素1-24（ACTH1-24）对近足月豚鼠分娩的影响。

Effect of maternal infusion of adrenocorticotrophin1-24 (ACTH1-24) on parturition in guinea-pigs near term.

作者信息

Schellenberg J C

机构信息

Research Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Auckland, New Zealand.

出版信息

Reprod Fertil Dev. 1997;9(8):811-4. doi: 10.1071/r97053.

DOI:10.1071/r97053

PMID:9733065

Abstract

While the mechanism of onset of labour in guinea-pigs is unknown, it has been suggested that administration of adrenocorticotrophin1-24 (ACTH1-24) near term induces labour. In order to verify this finding, guinea-pigs were fitted with indwelling carotid and jugular vascular cannulae. ACTH1-24 (30 microg h(-1) for four hours, n = 9) or vehicle (n = 5) was infused intravenously on Day 64 (term is 68 days). ACTH1-24 had no effect on gestational length (68.4+/-1.0 days, n = 6 v. control, 69.6+/-0.3 days, n = 5, P = 0.8). Symphysial width, fetal weight, number and viability were similar in both groups (all P > 0.1). Infusion of ACTH1-24 increased maternal ACTH concentrations from <1.8 pmol L(-1) to 34+/-6 pmol L(-1) (n = 6, P < 0.01) while fetal ACTH concentrations remained undetectable (n = 6). Infusion of ACTH1-24 increased cortisol concentrations in maternal plasma from 8.3+/-0.6 mmol L(-1) to 15.8+/-0.8 mmol L(-1) (n = 6, P < 0.001) but had no effect on concentrations of 13,14-dihydro-15-keto-PGF2alpha (P = 0.8). It is concluded that (1) maternal infusion of ACTH1-24 at the dosage used does not induce labour in guinea-pigs, and (2) ACTH1-24 does not cross the placenta.

摘要

虽然豚鼠分娩发动的机制尚不清楚，但有人提出在接近足月时给予促肾上腺皮质激素1 - 24（ACTH1 - 24）可诱发分娩。为了验证这一发现，给豚鼠植入了颈内动脉和颈静脉血管插管。在第64天（足月为68天）静脉输注ACTH1 - 24（30μg h⁻¹，持续4小时，n = 9）或赋形剂（n = 5）。ACTH1 - 24对妊娠期无影响（68.4±1.0天，n = 6，与对照组69.6±0.3天，n = 5相比，P = 0.8）。两组的耻骨联合宽度、胎儿体重、数量和活力相似（所有P > 0.1）。输注ACTH1 - 24使母体ACTH浓度从<1.8 pmol L⁻¹增加到34±6 pmol L⁻¹（n = 6，P < 0.01），而胎儿ACTH浓度仍无法检测到（n = 6）。输注ACTH1 - 24使母体血浆皮质醇浓度从8.3±0.6 mmol L⁻¹增加到15.8±0.8 mmol L⁻¹（n = 6，P < 0.001），但对13,14 - 二氢 - 15 - 酮 - PGF2α的浓度无影响（P = 0.8）。得出的结论是：（1）以所用剂量对母体输注ACTH1 - 24不会诱发豚鼠分娩，（2）ACTH1 - 24不会穿过胎盘。