Briquet M, Vilret D, Goblet P, Mesa M, Eloy M C
Unité de Biochimie Physiologique, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
J Bioenerg Biomembr. 1998 Jun;30(3):285-95. doi: 10.1023/a:1020553005293.
Helminthosporol is one of the natural sesquiterpenoid toxins isolated and identified in the culture medium of the phytopathogenic ascomycete fungus Cochliobolus sativus. The effect of this phytotoxin was investigated on enzymatic activities, electron and ion transport in mitochondria, chloroplasts, and microsomes of plant. The results indicate that helminthosporol drastically affects the membrane permeability of these organelles to protons and substrate anions, inhibiting the mitochondrial oxidative phosphorylation, the photophosphorylation in chloroplasts, and the proton pumping across the cell plasma membrane. The 1,3-beta-glucan synthase activity, involved in defense mechanisms of plant cells against stress and damage, e.g., during pathogen attack, was also strongly inhibited by the toxin.
蠕孢菌素是从植物病原子囊菌真菌玉米小斑病菌的培养基中分离并鉴定出的天然倍半萜毒素之一。研究了这种植物毒素对植物线粒体、叶绿体和微粒体中酶活性、电子和离子转运的影响。结果表明，蠕孢菌素极大地影响了这些细胞器对质子和底物阴离子的膜通透性，抑制了线粒体氧化磷酸化、叶绿体中的光合磷酸化以及质子跨细胞质膜的泵浦。参与植物细胞抵御应激和损伤（如病原体攻击期间）防御机制的1,3-β-葡聚糖合酶活性也受到该毒素的强烈抑制。
