N-[2-[5-[氨基（亚氨基）甲基]-2-羟基苯氧基]-3,5-二氟-6-[3-(4,5-二氢-1-甲基-1H-咪唑-2-基)苯氧基]吡啶-4-基]-N-甲基甘氨酸（ZK-807834）的发现：一种强效、选择性且口服活性的凝血酶因子Xa抑制剂。 - Suppr | 超能文献

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.

作者信息

Phillips G B, Buckman B O, Davey D D, Eagen K A, Guilford W J, Hinchman J, Ho E, Koovakkat S, Liang A, Light D R, Mohan R, Ng H P, Post J M, Shaw K J, Smith D, Subramanyam B, Sullivan M E, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey M M

机构信息

Discovery Research, Berlex Biosciences, 15049 San Pablo Avenue, P.O. Box 4099, Richmond, California 94804-0099, USA.

出版信息

J Med Chem. 1998 Sep 10;41(19):3557-62. doi: 10.1021/jm980280h.

DOI:10.1021/jm980280h

Abstract

摘要

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