Whitmarsh A J, Cavanagh J, Tournier C, Yasuda J, Davis R J
Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School and Howard Hughes Medical Institute, Worcester, MA 01605, USA.
Science. 1998 Sep 11;281(5383):1671-4. doi: 10.1126/science.281.5383.1671.
The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.
丝裂原活化蛋白（MAP）激酶中的c-Jun氨基末端激酶（JNK）组可通过使细胞暴露于多种应激形式而被激活。一种假定的支架蛋白被鉴定出来，它与JNK信号通路的多个组分相互作用，包括MAP激酶激酶激酶（MLK）的混合谱系组、MAP激酶激酶MKK7和MAP激酶JNK。这种支架蛋白通过MLK信号通路选择性增强JNK激活。这些数据表明，一种哺乳动物支架蛋白可介导MAP激酶信号通路的激活。
