Fuerstenberg S, Giniger E
Fred Hutchinson Cancer Research Center, Basic Science Division, 1100 Fairview Avenue N,Seattle, Washington 98109, USA.
Dev Biol. 1998 Sep 1;201(1):66-77. doi: 10.1006/dbio.1998.8944.
Notch plays a role in many cell fate decisions in the developing Drosophila embryo, often at successive stages during the formation of a single tissue. In the embryonic mesoderm, Notch is involved in the process by which muscle progenitors are selected from a field of equivalent myoblasts. We have investigated the roles of Notch in somatic myogenesis and show that Notch can affect at least two additional steps in muscle development. Subsequent to the initial specification of progenitors, myoblast identity remains sensitive to mesodermal Notch activity until the time of fusion. Additionally, Notch is capable of suppressing muscle development nonautonomously by regulating a signal that emanates from the ectoderm.
Notch在发育中的果蝇胚胎的许多细胞命运决定中发挥作用，通常是在单个组织形成过程中的连续阶段。在胚胎中胚层，Notch参与了从一群等效的成肌细胞中选择肌肉祖细胞的过程。我们研究了Notch在体细胞肌生成中的作用，并表明Notch至少可以影响肌肉发育中的另外两个步骤。在祖细胞最初被指定之后，成肌细胞的身份在融合之前一直对中胚层Notch活性敏感。此外，Notch能够通过调节来自外胚层的信号非自主地抑制肌肉发育。
