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长春碱对更新细胞中DNA代谢的影响(作者译)

[The effect of vinblastine on DNA metabolism in turnover cells (author's transl)].

作者信息

Cabela E, Klein W

出版信息

Wien Klin Wochenschr. 1976 Apr 30;88(9):299-302.

PMID:973390
Abstract

Studies on the effect of Vinblastine on normal and tumour cell show that semi-conservative DNA synthesis correlates with the enzymatic activity of thymidine kinase. DNA repair investigations performed with Yoshida-Ascites cells indicate an inhibitory effect on the ligase system after Vinblastine treatment and gamma irradiation.

摘要

关于长春碱对正常细胞和肿瘤细胞作用的研究表明,半保留DNA合成与胸苷激酶的酶活性相关。用吉田腹水细胞进行的DNA修复研究表明,长春碱处理和γ射线照射后对连接酶系统有抑制作用。

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