Hida H, Faber M, Alberto-Gondouin M C, Jalaguier E
Centre Hospitalier de Saint-Egrève, France.
Therapie. 1997 Nov-Dec;52(6):573-8.
A study on the prescription of psychotropic drugs was carried out at St-Egreve Psychiatric Hospital (Isère,--France) based on in-patient prescriptions (adults only). Analysis of the 200 prescriptions issued by 26 different practitioners found an average of 3.3 psychotropic drugs per patient (including 1.7 neuroleptics). A combination of neuroleptics was very frequent (63 pour cent of the schizophrenics receiving at least 2 neuroleptics). Half of the patients treated with neuroleptics received antiparkinsonian drugs. The other psychotropic medications often combined with neuroleptics, were anxiolytics (50 per cent), hypnotics (45 per cent), antidepressants (28 per cent) and normothymics (25 per cent). Among the antidepressants, the SSRI were the most commonly prescribed, even above tricyclics, reflecting their better clinical tolerance. The significant differences in prescribing practice between the services prompted the creation of a working group comprising practitioners and pharmacists to study the prescription of psychotropic drugs and compare this with the literature.
一项关于精神药物处方的研究在法国伊泽尔省圣埃格勒夫精神病院开展，该研究基于住院患者（仅限成人）的处方。对26位不同从业者开出的200份处方进行分析后发现，每位患者平均使用3.3种精神药物（其中包括1.7种抗精神病药物）。联合使用抗精神病药物的情况非常常见（63%的精神分裂症患者至少使用2种抗精神病药物）。接受抗精神病药物治疗的患者中有一半同时服用了抗帕金森病药物。其他常与抗精神病药物联合使用的精神药物包括抗焦虑药（50%）、催眠药（45%）、抗抑郁药（28%）和心境稳定剂（25%）。在抗抑郁药中，选择性5-羟色胺再摄取抑制剂（SSRI）的处方量最为常见，甚至超过了三环类抗抑郁药，这反映出它们具有更好的临床耐受性。各科室在处方习惯上的显著差异促使成立了一个由从业者和药剂师组成的工作组，以研究精神药物的处方情况，并与相关文献进行比较。
