Adamson T A
Neuropsychiatric Hospital, Aro-Abeokuta, Nigeria.
Afr J Med Med Sci. 1995 Sep;24(3):261-7.
The study evaluated the prescribing habits of psychotropic drugs in a psychiatric set-up. It revealed that neuroleptics were the most frequently prescribed psychotropic drugs, as they were given to 88% of the 170 patients placed on admission during the study period. They also formed a major part of the treatment of patients with depressive illness, where their combination with antidepressant drugs were more frequently prescribed than antidepressants alone. Depot neuroleptics were not used only as maintenance drugs or for patients with poor oral compliance, but prescribed as stat doses given once daily, in 16% of the patients. Antiparkinsonian drugs were frequently prescribed and were not necessarily commenced after the development of extrapyramidal side effects, as one-third of the patients on them had the drugs prescribed on the first day of treatment. A combination of two or more drugs, administered frequently per day was common. Prescribing instructions for pro re nate (p.r.n.) drugs were inadequate. The study highlights areas of improvement in prescribing habit over earlier studies and further reveals the ones that need to be improved especially in an economy that can least afford wastage.
该研究评估了精神科环境中精神药物的处方习惯。研究表明,抗精神病药物是最常处方的精神药物,在研究期间入院的170名患者中,有88%的患者使用了此类药物。它们也是抑郁症患者治疗的主要组成部分,与抗抑郁药物联合使用的处方比单独使用抗抑郁药物更为常见。长效抗精神病药物不仅用于维持治疗或口服依从性差的患者,在16%的患者中,还作为每日一次的单次剂量处方。抗帕金森病药物的处方很常见,且不一定在锥体外系副作用出现后才开始使用,因为三分之一使用此类药物的患者在治疗第一天就开了药。每天频繁使用两种或更多药物的联合用药很常见。按需给药(p.r.n.)药物的处方说明不充分。该研究突出了与早期研究相比处方习惯的改进领域,并进一步揭示了那些尤其在最无法承受浪费的经济体中需要改进的方面。