Blasi C, D'Amore F, Levati M, Bandinelli M C
Ospedale Sandro Pertini di Roma.
Ann Ital Med Int. 1998 Apr-Jun;13(2):111-6.
Two cases of neuroleptic malignant syndrome are reported. Although affecting chiefly psychiatric patients, this rare, polymorphic disease should be well-known to internists, general practitioners, and emergency staff because of its high risk of fatality. Our patients, who presented without some of the main symptoms, fell in the category of incomplete variants of the syndrome, the most difficult to recognize. In both patients, computerized tomography carried out at the outset of symptoms, evidenced signs of cerebral edema, a datum never before reported. The symptomatic polymorphism, pathogenesis, differential diagnosis, and therapy of this disease are illustrated and discussed.
报告了两例抗精神病药物恶性综合征。尽管该罕见的多形性疾病主要影响精神科患者，但因其高致死风险，内科医生、全科医生及急诊医护人员都应充分了解。我们的患者未表现出某些主要症状，属于该综合征最难识别的不完全变异类型。两名患者在症状出现之初进行的计算机断层扫描均显示有脑水肿迹象，这一情况此前未见报道。本文对该疾病的症状多形性、发病机制、鉴别诊断及治疗进行了阐述和讨论。
