平滑肌肌球蛋白的分子机制。

The molecular mechanics of smooth muscle myosin.

作者信息

Guilford W H, Warshaw D M

机构信息

University of Vermont, Department of Molecular Physiology and Biophysics, College of Medicine, Burlington 05405, USA.

出版信息

Comp Biochem Physiol B Biochem Mol Biol. 1998 Mar;119(3):451-8. doi: 10.1016/s0305-0491(98)00002-9.

DOI:10.1016/s0305-0491(98)00002-9

PMID:9734329

Abstract

Smooth muscle cells are capable of generating forces comparable to those of skeletal muscle cells but with far less myosin, the molecular motor that powers muscle contraction. This unique capability may be inherent to the myosin molecule. We have directly characterized the molecular mechanics of smooth muscle myosin using new technologies developed to measure the forces generated by these proteins. The data help explain the differences in force and velocity in whole smooth and skeletal muscles.

摘要

平滑肌细胞能够产生与骨骼肌细胞相当的力量，但所需的肌球蛋白却少得多，肌球蛋白是驱动肌肉收缩的分子马达。这种独特的能力可能是肌球蛋白分子所固有的。我们利用新开发的技术直接表征了平滑肌肌球蛋白的分子力学，这些技术用于测量这些蛋白质产生的力量。这些数据有助于解释整个平滑肌和骨骼肌在力量和速度上的差异。