Piccinni M P, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S
Institute of Internal Medicine and Immunoallergology, University of Florence, Italy.
Nat Med. 1998 Sep;4(9):1020-4. doi: 10.1038/2006.
Leukemia inhibitory factor is essential for embryo implantation, and a shift from type 1 T-helper to type 2 T-helper response at the fetal-maternal interface may contribute to successful pregnancy. We show that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated by IL-12, IFN-gamma and IFN-alpha. We also show a decreased production of LIF, IL-4 and IL-10 by decidual T cells of women with unexplained recurrent abortions in comparison with that of women with normal gestation. The defective production of LIF and/or type 2 T-helper cytokines may contribute to the development of unexplained recurrent abortions.
白血病抑制因子对胚胎着床至关重要，胎儿 - 母体界面处从1型辅助性T细胞向2型辅助性T细胞反应的转变可能有助于成功妊娠。我们发现白血病抑制因子的产生与2型辅助性T细胞相关，受白细胞介素 - 4和孕酮上调，而受白细胞介素 - 12、干扰素 - γ和干扰素 - α下调。我们还发现，与正常妊娠女性相比，原因不明的复发性流产女性的蜕膜T细胞产生的白血病抑制因子、白细胞介素 - 4和白细胞介素 - 10减少。白血病抑制因子和/或2型辅助性T细胞细胞因子产生缺陷可能导致原因不明的复发性流产的发生。
