二氧化碳诱发的惊恐发作：一项双胞胎研究。
CO2-induced panic attacks: a twin study.
作者信息
Bellodi L, Perna G, Caldirola D, Arancio C, Bertani A, Di Bella D
机构信息
Department of Neuropsychiatric Sciences, Istituto Scientifico H.S. Raffaele, Milan, Italy.
出版信息
Am J Psychiatry. 1998 Sep;155(9):1184-8. doi: 10.1176/ajp.155.9.1184.
OBJECTIVE
The authors investigated the role of genetic factors in 35% CO2-induced panic attacks.
METHOD
Ninety twins recruited from the general population were challenged with one-vital-capacity inhalations of 35% CO2-65% O2. Probandwise concordance rates were calculated and rates compared for monozygotic and for dizygotic twins.
RESULTS
A significantly higher concordance was found for 35% CO2-induced panic attacks among monozygotic than dizygotic twins (55.6% versus 12.5%).
CONCLUSIONS
These results suggest a relevant role of genetic factors in 35% CO2-induced panic attacks.
目的
作者研究了遗传因素在35%二氧化碳诱发惊恐发作中的作用。
方法
从普通人群中招募了90对双胞胎，让他们进行一次肺活量吸入35%二氧化碳 - 65%氧气的激发试验。计算先证者一致率，并比较同卵双胞胎和异卵双胞胎的一致率。
结果
发现同卵双胞胎中由35%二氧化碳诱发的惊恐发作一致率显著高于异卵双胞胎（55.6%对12.5%）。
结论
这些结果表明遗传因素在35%二氧化碳诱发的惊恐发作中起相关作用。
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