Djoussé L, Ellison R C, Zhang Y, Arnett D K, Sholinsky P, Borecki I
Evans Department of Medicine, Boston University School of Medicine, 02118, USA.
Am J Clin Nutr. 1998 Sep;68(3):568-75. doi: 10.1093/ajcn/68.3.568.
Considerable evidence suggests that high plasma concentrations of plasminogen activator inhibitor type 1 (PAI-1) and fibrinogen increase the risk of cardiovascular disease. Recent studies report beneficial effects of dietary fiber on coronary artery disease, although the mechanisms by which high fiber intake reduces the risk of heart disease are not well understood. This study examined the relation of dietary fiber intake to PAI-1 and fibrinogen concentrations in 883 men and 1116 women aged 50.4 +/- 13.8 and 52.1 +/- 13.7 y, respectively, in the National Heart, Lung, and Blood Institute Family Heart Study. Diet was assessed with a semiquantitative food-frequency questionnaire. The natural logarithm was used to transform PAI-1 because of a skewed distribution. In the first through fifth age- and energy-specific quintiles of fiber intake, mean (ln)PAI-1 was 6.09, 5.91, 5.88, 5.82, and 5.67 pmol/L, respectively, for men and 5.50, 5.37, 5.39, 5.23, and 5.18 pmol/L, respectively, for women. Multiple regression showed that when the lowest was compared with the second, third, fourth, and fifth age- and energy-specific quintiles of fiber intake, (ln)PAI-1 was 0.21, 0.25, 0.22, and 0.32 pmol/L lower in men (P for trend = 0.009) and 0.08, 0.06, 0.14, and 0.20 pmol/L lower in women (P for trend = 0.037), respectively, with anthropometric, lifestyle, and metabolic factors adjusted for. No significant association was found between fiber intake and fibrinogen. Waist-hip ratio did not modify the relation of fiber intake to PAI-1 (P for interaction = 0.39 for men and 0.36 for women). These data suggest that higher fiber intake is inversely associated with PAI-1, but not with fibrinogen concentration.
大量证据表明，血浆中纤溶酶原激活物抑制剂1型（PAI-1）和纤维蛋白原的高浓度会增加心血管疾病的风险。近期研究报告了膳食纤维对冠状动脉疾病的有益作用，尽管高纤维摄入量降低心脏病风险的机制尚不清楚。本研究在国立心肺血液研究所家族心脏研究中，分别对883名年龄为50.4±13.8岁的男性和1116名年龄为52.1±13.7岁的女性，研究了膳食纤维摄入量与PAI-1和纤维蛋白原浓度之间的关系。通过半定量食物频率问卷评估饮食情况。由于PAI-1分布呈偏态，因此采用自然对数进行转换。在按年龄和能量划分的纤维摄入量的第一至第五分位数中，男性的平均（ln）PAI-1分别为6.09、5.91、5.88、5.82和5.67 pmol/L，女性分别为5.50、5.37、5.39、5.23和5.18 pmol/L。多元回归分析显示，将最低纤维摄入量分位数与第二、第三、第四和第五年龄及能量特定分位数进行比较时，校正人体测量学、生活方式和代谢因素后，男性的（ln）PAI-1分别低0.21、0.25、0.22和0.32 pmol/L（趋势P值=0.009），女性分别低0.08、0.06、0.14和0.20 pmol/L（趋势P值=0.037）。未发现纤维摄入量与纤维蛋白原之间存在显著关联。腰臀比并未改变纤维摄入量与PAI-1之间的关系（男性交互作用P值=0.39，女性为0.36）。这些数据表明，较高的纤维摄入量与PAI-1呈负相关，但与纤维蛋白原浓度无关。
