Teegarden D, Lyle R M, McCabe G P, McCabe L D, Proulx W R, Michon K, Knight A P, Johnston C C, Weaver C M
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-1264, USA.
Am J Clin Nutr. 1998 Sep;68(3):749-54. doi: 10.1093/ajcn/68.3.749.
Dietary factors have been implicated in modifying bone health, although the results remain controversial, particularly in young women.
The objective of the study was to determine relations of selected dietary factors and anthropometric measurements to bone mineral density (BMD) of the spine, femoral neck, trochanter, Ward's triangle, radius, and total body and the bone mineral content (BMC) of the spine, radius, and total body.
The study was a cross-sectional analysis of 215 women aged 18-31 y.
Weight, height, and lean mass were correlated with bone mineral measures at every site (r = 0.17-0.78). Postmenarcheal age (years since onset of menses) was positively correlated with total-body BMD and BMC, radius BMD and BMC, and spine BMC, and negatively correlated with Ward's triangle BMD. Radius BMD was correlated with protein, calcium, and phosphorus intakes, and spine BMD and BMC were correlated with energy, protein, calcium, and phosphorus intakes. These correlations remained significant when postmenarcheal age, lean mass, and fat mass were controlled. A pattern emerged in multiple regression analyses that showed a complex relation among calcium, protein or phosphorus, and the calcium-protein or calcium-phosphorus ratio and spine or total-body BMC and BMD. All 3 variables (calcium, protein or phosphorus, and calcium-protein or calcium-phosphorus ratio) were required in the model for significance.
Anthropometric measures were predictors of bone mass. A single ratio of calcium to phosphorus or protein did not optimize bone mass across the range of calcium intakes.
饮食因素与骨骼健康的改善有关，尽管结果仍存在争议，尤其是在年轻女性中。
本研究的目的是确定特定饮食因素和人体测量指标与脊柱、股骨颈、大转子、Ward三角区、桡骨、全身的骨矿物质密度（BMD）以及脊柱、桡骨和全身的骨矿物质含量（BMC）之间的关系。
该研究是对215名年龄在18 - 31岁女性的横断面分析。
体重、身高和瘦体重与各个部位的骨矿物质测量值相关（r = 0.17 - 0.78）。月经初潮后年龄（月经开始后的年数）与全身BMD和BMC、桡骨BMD和BMC以及脊柱BMC呈正相关，与Ward三角区BMD呈负相关。桡骨BMD与蛋白质、钙和磷的摄入量相关，脊柱BMD和BMC与能量、蛋白质、钙和磷的摄入量相关。在控制月经初潮后年龄、瘦体重和脂肪量后，这些相关性仍然显著。多元回归分析中出现了一种模式，显示钙、蛋白质或磷以及钙 - 蛋白质或钙 - 磷比例与脊柱或全身BMC和BMD之间存在复杂关系。模型中所有3个变量（钙、蛋白质或磷以及钙 - 蛋白质或钙 - 磷比例）都需要具有显著性。
人体测量指标是骨量的预测因素。单一的钙与磷或蛋白质的比例并不能在钙摄入量范围内优化骨量。
