Interferon-alpha treatment of four patients with the Churg-Strauss syndrome.

BACKGROUND

Interferon-alpha is reported to have a beneficial effect on patients with the idiopathic hypereosinophilic syndrome.

OBJECTIVE

To study the effect of interferon-alpha on the Churg-Strauss syndrome.

DESIGN

Case series.

SETTING

University hospital.

PATIENTS

Four patients with biopsy-proven Churg-Strauss syndrome.

INTERVENTION

Interferon-alpha at dosages of 7.5 to 63 million U per week.

MEASUREMENTS

Disease extent, disease activity, and blood eosinophil count in a treatment period ranging from 14 to 25 months.

RESULTS

Interferon-alpha therapy led to remission of disease and a substantial reduction of the prednisolone requirement in two patients who had attained incomplete remission with cyclophosphamide or methotrexate. The third patient's condition stabilized, and the fourth patient maintained remission. During interferon-alpha therapy, the blood eosinophil count in all patients decreased in a dose-dependent manner and paralleled the extent of clinical disease and disease activity.

CONCLUSIONS

Interferon-alpha may be an effective treatment for the Churg-Strauss syndrome. It seems to exert its effect primarily by producing a dose-dependent decrease in the blood eosinophil count.