Shearer W T
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Prim Care. 1998 Dec;25(4):759-74. doi: 10.1016/s0095-4543(05)70086-5.
The entry of one HIV virion into a human being has the potential to cause death by the inexorable replication of the virus within the principal T lymphocyte, the CD4+ T cell. Although combination antiretroviral therapy, particularly therapy with protease inhibitors, decreases the viral burden to very low, even undetectable, levels, sequestration of the virus in privileged sites, including a long-lived CD4+ T cell, has frustrated efforts at eradication of HIV. Activation of the immune system, therefore, appears essential before this infection can be conquered. Powerful vaccines capable of preventing infection remain the hope of the world.
一个HIV病毒粒子进入人体后，有可能通过该病毒在主要的T淋巴细胞即CD4 + T细胞内不断复制而导致死亡。尽管联合抗逆转录病毒疗法，尤其是蛋白酶抑制剂疗法可将病毒载量降低到非常低甚至检测不到的水平，但病毒在包括长寿CD4 + T细胞在内的特权部位的隐匿，阻碍了根除HIV的努力。因此，在攻克这种感染之前，激活免疫系统似乎至关重要。能够预防感染的强效疫苗仍是全世界的希望所在。
