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甲状腺乳头状癌:全甲状腺切除术的依据及淋巴结转移的处理

Papillary thyroid carcinoma: justification for total thyroidectomy and management of lymph node metastases.

作者信息

Chen H, Udelsman R

机构信息

Division of Surgical Oncology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Surg Oncol Clin N Am. 1998 Oct;7(4):645-63.

PMID:9735127
Abstract

Papillary thyroid carcinoma (PTC) is the most common epithelial thyroid tumor and comprises approximately 80% of all thyroid cancers. In this article, the authors discuss the data showing that total thyroidectomy is the treatment of choice of clinically significant PTC, and review an algorithm for the management of lymph node metastases. Although the prognosis for patients with PTC is generally good, appropriate surgical management (total thyroidectomy plus 131I and life-long TSH suppression) can further reduce recurrence and cancer death rates significantly.

摘要

乳头状甲状腺癌(PTC)是最常见的甲状腺上皮性肿瘤,约占所有甲状腺癌的80%。在本文中,作者讨论了表明全甲状腺切除术是具有临床意义的PTC的首选治疗方法的数据,并回顾了一种淋巴结转移的管理算法。尽管PTC患者的预后总体良好,但适当的手术管理(全甲状腺切除术加131I和终身促甲状腺激素抑制)可进一步显著降低复发率和癌症死亡率。

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Papillary thyroid carcinoma: justification for total thyroidectomy and management of lymph node metastases.甲状腺乳头状癌:全甲状腺切除术的依据及淋巴结转移的处理
Surg Oncol Clin N Am. 1998 Oct;7(4):645-63.
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What is the biology and optimal treatment for papillary microcarcinoma of the thyroid?甲状腺微小乳头状癌的生物学特性及最佳治疗方法是什么?
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Biologic considerations and operative strategy in papillary thyroid carcinoma: arguments against the routine performance of total thyroidectomy.甲状腺乳头状癌的生物学考量与手术策略:反对常规行甲状腺全切除术的理由
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引用本文的文献

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'Aggressive papillary' thyroid microcarcinoma.侵袭性甲状腺微小乳头状癌。
Eur Arch Otorhinolaryngol. 2009 Dec;266(12):1959-63. doi: 10.1007/s00405-009-0952-5. Epub 2009 Mar 18.
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Multi-targeted approach in the treatment of thyroid cancer.甲状腺癌的多靶点治疗方法。
Ther Clin Risk Manag. 2008 Oct;4(5):935-47. doi: 10.2147/tcrm.s3062.
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Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors.Notch1通过组蛋白去乙酰化酶抑制剂介导乳头状和滤泡状甲状腺癌细胞的生长抑制。
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Special variants of differentiated thyroid cancer: does it alter the extent of surgery versus well-differentiated thyroid cancer?分化型甲状腺癌的特殊变体:与分化良好的甲状腺癌相比,它是否会改变手术范围?
World J Surg. 2007 May;31(5):916-23. doi: 10.1007/s00268-006-0837-3.
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Thyroid cancer surgery.甲状腺癌手术
Rev Endocr Metab Disord. 2000 Apr;1(3):155-63. doi: 10.1023/a:1010022913415.