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核糖体循环因子(RRF)介导的终止后复合物解离及翻译错误减少——抗菌药物的一个可能新靶点

Disassembly of the post-termination complex and reduction of translational error by ribosome recycling factor (RRF)-A possible new target for antibacterial agents.

作者信息

Kaji A, Teyssier E, Hirokawa G

机构信息

School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.

出版信息

Biochem Biophys Res Commun. 1998 Sep 8;250(1):1-4. doi: 10.1006/bbrc.1998.9168.

DOI:10.1006/bbrc.1998.9168
PMID:9735320
Abstract

In this paper, we briefly review RRF (ribosome recycling factor, previously called ribosome releasing factor) (for recent reviews covering historical background see (1, 2)).

摘要

在本文中,我们简要回顾核糖体循环因子(RRF,以前称为核糖体释放因子)(有关涵盖历史背景的近期综述,请参阅(1, 2))。

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1
Disassembly of the post-termination complex and reduction of translational error by ribosome recycling factor (RRF)-A possible new target for antibacterial agents.核糖体循环因子(RRF)介导的终止后复合物解离及翻译错误减少——抗菌药物的一个可能新靶点
Biochem Biophys Res Commun. 1998 Sep 8;250(1):1-4. doi: 10.1006/bbrc.1998.9168.
2
Release factor RF3 abolishes competition between release factor RF1 and ribosome recycling factor (RRF) for a ribosome binding site.释放因子RF3消除了释放因子RF1与核糖体循环因子(RRF)之间对核糖体结合位点的竞争。
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[Ribosome recycling factor (RRF): a factor which disassemble the post-termination complex and reduces translational error].核糖体循环因子(RRF):一种可拆解终止后复合物并减少翻译错误的因子
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Ribosome recycling factor disassembles the post-termination ribosomal complex independent of the ribosomal translocase activity of elongation factor G.核糖体循环因子可独立于延伸因子G的核糖体转位酶活性来拆解终止后的核糖体复合物。
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Fast recycling of Escherichia coli ribosomes requires both ribosome recycling factor (RRF) and release factor RF3.大肠杆菌核糖体的快速循环需要核糖体循环因子(RRF)和释放因子RF3。
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Evidence for in vivo ribosome recycling, the fourth step in protein biosynthesis.体内核糖体循环(蛋白质生物合成的第四步)的证据。
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Dual functions of ribosome recycling factor in protein biosynthesis: disassembling the termination complex and preventing translational errors.核糖体循环因子在蛋白质生物合成中的双重功能:拆解终止复合物并防止翻译错误。
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