Leung K H, Pippalla V, Kreutter A, Chandler M
Department of Cell Biology, Human Genome Sciences, Inc., Rockville, Maryland, 20850, USA.
Biochem Biophys Res Commun. 1998 Sep 8;250(1):137-42. doi: 10.1006/bbrc.1998.9279.
We studied the effects of FGF-13 and FGF-2 on human lung fibroblasts, dermal microvascular endothelial cells, and aortic smooth muscle cells. FGF-13 induced cell growth of lung fibroblasts and aortic smooth muscle cells but had no effect on dermal vascular endothelial cells. FGF-2 induced cell growth in all the three cell types. FGF-13 and FGF-2 had little effect on IL-6 production by lung fibroblasts and aortic smooth muscle cells and substantially enhanced that induced by IL-1alpha. In contrast, FGF-13 and FGF-2 had little effect on IL-6 production by dermal vascular endothelial cells, either alone or in synergy with IL-1alpha.
我们研究了FGF-13和FGF-2对人肺成纤维细胞、真皮微血管内皮细胞和主动脉平滑肌细胞的影响。FGF-13可诱导肺成纤维细胞和主动脉平滑肌细胞生长，但对真皮血管内皮细胞无影响。FGF-2可诱导这三种细胞类型生长。FGF-13和FGF-2对肺成纤维细胞和主动脉平滑肌细胞产生白细胞介素-6（IL-6）的影响较小，且显著增强了IL-1α诱导的IL-6产生。相比之下，FGF-13和FGF-2无论是单独作用还是与IL-1α协同作用，对真皮血管内皮细胞产生IL-6的影响都较小。
