Meier J H, Rutten W L, Boom H B
Biomedical Engineering Department, Faculty of Electrical Engineering/Institute for Biomedical Technology, University of Twente, The Netherlands.
IEEE Trans Biomed Eng. 1998 Sep;45(9):1146-53. doi: 10.1109/10.709558.
A model is presented that calculates the single-fiber extracellular field and action potential (ap) of an active myelinated nerve fiber placed centrally or eccentrically inside a nerve with a cylindrical geometry, representing essentially a one-fascicle nerve. This one-fascicle nerve has the dimensions and conductivities of the rat peroneal nerve branch. The results show a wide variety of wave shapes to be measured, depending on the position of the intraneural electrode with respect to the fiber axis and to the nodes of Ranvier and depending on the presence of an isolating cuff around the nerve. Action potential shapes may range from the "classical" quasi-biphasic one, to more triphasic, or even more complicated in the case of a short insulating cuff being present around the nerve. In the latter case, when measured bipolarly, ap-wave shapes become almost monophasic.
本文提出了一个模型，用于计算置于具有圆柱几何形状的神经内部（中心或偏心位置）的活性有髓神经纤维的单纤维细胞外场和动作电位（ap），该神经本质上代表单束神经。这个单束神经具有大鼠腓神经分支的尺寸和电导率。结果表明，根据神经内电极相对于纤维轴和郎飞结的位置以及神经周围是否存在隔离套，可测量到多种波形。动作电位形状范围可能从“经典”的准双相形状，到更多的三相形状，甚至在神经周围存在短绝缘套的情况下会更复杂。在后一种情况下，当进行双极测量时，动作电位波形几乎变为单相。
