Veltink P H, van Veen B K, Struijk J J, Holsheimer J, Boom H B
IEEE Trans Biomed Eng. 1989 Jul;36(7):683-92. doi: 10.1109/10.32100.
A nerve stimulation model has been developed, incorporating realistic cross-sectional nerve geometries and conductivities. The potential field in the volume conductor was calculated numerically using the variational method. Nerve fiber excitation was described by the model of McNeal. Cross-sectional geometries of small monofascicular rat common peroneal nerve and multifascicular human deep peroneal nerve were taken as sample geometries. Selective stimulation of a fascicle was theoretically analyzed for several electrode positions: outside the nerve, in the connective tissue of the nerve, and inside a fascicle. The model results predict that the use of intraneural or even intrafascicular electrodes is necessary for selective stimulation of fascicles not lying at the surface of the nerve. Model predictions corresponded with experimental results of Veltink et al. on intrafascicular and extraneural stimulation of rat common peroneal nerve and to results of McNeal and Bowman on muscle selective stimulation in multifascicular dog sciatic nerve using an extraneural multielectrode configuration.
已开发出一种神经刺激模型，该模型纳入了实际的神经横截面几何形状和电导率。使用变分法对体积导体中的电位场进行了数值计算。神经纤维兴奋由麦克尼尔模型描述。以小型单束大鼠腓总神经和多束人腓深神经的横截面几何形状作为样本几何形状。针对几个电极位置对束的选择性刺激进行了理论分析：在神经外部、在神经的结缔组织中以及在束内。模型结果预测，对于不在神经表面的束的选择性刺激，需要使用神经内甚至束内电极。模型预测与韦尔廷克等人关于大鼠腓总神经束内和神经外刺激的实验结果以及麦克尼尔和鲍曼关于使用神经外多电极配置对多束犬坐骨神经进行肌肉选择性刺激的结果相符。
