Librowski T, Filipek B, Czarnecki R, Beresewicz A, Karwatowska-Prokopczuk E
Department of Pharmacodynamics, Collegium Medicum Jagiellonian University, Kraków, Poland.
Acta Pol Pharm. 1998 May-Jun;55(3):243-7.
Antiarrhythmic effects and intracellular electrophysiological properties of a new antiarrhythmic compound (-)trans-4-[2-hydroxy-3(N-isopropylamino)-propoxyimino]-cis-car ane (9) were studied in several models of arrhythmia and in isolated guinea-pig myocardial preparations. Compound 9 prevented the aconitine-induced arrhythmia, reversed the ouabin-induced arrhythmia depressed the maximum rate depolarization (Vmax), and shortened the action potential duration (ADP) and the effective refractory period (ERP). The data indicate that compound 9 is an effective antiarrhythmic presumably with a class 1 B mechanism of action.
在多种心律失常模型及离体豚鼠心肌标本中，研究了一种新型抗心律失常化合物（-）反式-4-[2-羟基-3（N-异丙基氨基）-丙氧基亚氨基]-顺式蒈烷（9）的抗心律失常作用及细胞内电生理特性。化合物9可预防乌头碱诱发的心律失常，逆转哇巴因诱发的心律失常，降低最大去极化速率（Vmax），缩短动作电位时程（ADP）及有效不应期（ERP）。数据表明化合物9是一种有效的抗心律失常药物，其作用机制可能为ⅠB类。
