致密斑功能中的前列腺素

Prostaglandins in macula densa function.

作者信息

Harris R C, Wang J L, Cheng H F, Zhang M Z, McKanna J A

机构信息

George M. O'Brien Kidney and Urologic Diseases Center and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

出版信息

Kidney Int Suppl. 1998 Sep;67:S49-52. doi: 10.1046/j.1523-1755.1998.06710.x.

DOI:10.1046/j.1523-1755.1998.06710.x

PMID:9736253

Abstract

Cyclooxygenase (COX)-2 mRNA and immunoreactive protein localize to the macula densa and adjacent cortical thick ascending limb in renal cortex, and chronic NaCl restriction increases expression of this enzyme. These findings suggest an integral role for eicosanoids generated by macula densa-associated COX-2 in mediating renin release. As selective inhibitors of COX-2 become available, it will be important to assess their effects on the renin-angiotensin system and glomerular hemodynamics.

摘要

环氧化酶（COX）-2信使核糖核酸及免疫反应性蛋白定位于肾皮质的致密斑及相邻的皮质厚升支，慢性氯化钠限制可增加该酶的表达。这些发现提示致密斑相关的COX-2所产生的类花生酸在介导肾素释放中起重要作用。随着COX-2选择性抑制剂的出现，评估它们对肾素-血管紧张素系统及肾小球血流动力学的影响将很重要。