Rovenský J, Blazícková S, Rauová L, Jezová D, Koska J, Lukác J, Vigas M
Research Institute for Rheumatic Diseases, Piest'any, Slovak Republic.
Lupus. 1998;7(6):409-13. doi: 10.1191/096120398678920325.
It has been suggested that neuroendocrine regulation plays an important role in the pathogenesis and activation of autoimmune diseases. The aim of this investigation was to clarify the hypothalamic-pituitary response to a well-defined stimulus under standardised conditions in patients with SLE. Plasma concentrations of prolactin (PRL), growth hormone (GH) and cortisol were determined in venous blood drawn through an indwelling cannula during insulin-induced hypoglycaemia (0.1 U/kg b.w., i.v.) in ten patients and in 12 age-, gender- and weight-matched healthy subjects. Basal PRL concentrations were higher in patients vs healthy controls (12 vs 6 ng/ml, P < 0.01), though still within the physiological range. Insulin-induced plasma PRL and GH were significantly increased both in patients and healthy subjects; however, the increments or areas under the curves were not different in the two groups. Plasma cortisol response showed moderate attenuation in patients. Sensitivity of pituitary lactotrothrops to thyrotropin-releasing hormone (TRH) administration (200 microg, i.v.) was the same in patients and control subjects. In SLE patients with low activity of the disease the sensitivity of pituitary PRL release to TRH administration remained unchanged. The hypothalamic response to stress stimulus (hypoglycaemia) was comparable in patients and healthy subjects.
有人提出，神经内分泌调节在自身免疫性疾病的发病机制和激活过程中起着重要作用。本研究的目的是在标准化条件下，明确系统性红斑狼疮（SLE）患者下丘脑 - 垂体对明确刺激的反应。在10例患者和12例年龄、性别及体重匹配的健康受试者中，于胰岛素诱导的低血糖（0.1 U/kg体重，静脉注射）期间，通过留置套管采集静脉血，测定血浆催乳素（PRL）、生长激素（GH）和皮质醇的浓度。患者的基础PRL浓度高于健康对照组（12 vs 6 ng/ml，P < 0.01），但仍在生理范围内。胰岛素诱导后，患者和健康受试者的血浆PRL和GH均显著升高；然而，两组的增量或曲线下面积并无差异。患者的血浆皮质醇反应呈中度减弱。垂体催乳素细胞对促甲状腺激素释放激素（TRH）给药（200μg，静脉注射）的敏感性在患者和对照受试者中相同。在疾病活动度低的SLE患者中，垂体PRL释放对TRH给药的敏感性保持不变。患者和健康受试者下丘脑对应激刺激（低血糖）的反应相当。
