Barr S C, Bowman D D, Frongillo M F, Joseph S L
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Am J Vet Res. 1998 Sep;59(9):1134-6.
To evaluate efficacy of a combination of praziquantel, pyrantel pamoate, and febantel at 2 dosages for treating naturally acquired giardiasis in dogs.
6 male and 9 female Beagles.
Dogs were identified as naturally infected with Giardia sp, using the zinc sulfate concentration technique (ZSCT), and were allocated to 1 of 3 groups. Group-1 dogs were treated orally with a praziquantel (5.4 to 7 mg/kg of body weight), pyrantel pamoate (26.8 to 35.2 mg/kg), and febantel (26.8 to 35.2 mg/kg) combination, every 24 hours for 3 doses. Group-2 dogs were treated with the combination once. Group-3 dogs were nontreated controls. Four fecal samples were examined, using the ZSCT, from each dog of each group within 6 days of the last treatment. Dogs were considered to have giardiasis if 1 or more of the fecal samples had positive results for Giardia cysts. Dogs were examined daily for at least 10 days after the last treatment.
Giardia cysts were not detected in the feces of any group-1 dog or in the feces of 2 of 5 group-2 dogs. Cysts were detected in the feces of 5 of 5 group-3 (nontreated control) dogs. Signs of toxicosis were not observed in any dog.
The current labeled dose (for treatment of various nematodes and cestodes, but not Giardia sp) of the combination given orally once reduces cyst excretion in Giardia-infected dogs, and should be considered for treatment of dogs shedding Giardia cysts, whether or not they have clinical signs of infection.
评估吡喹酮、双羟萘酸噻嘧啶和非班太尔联合用药两种剂量治疗犬自然感染贾第虫病的疗效。
6只雄性和9只雌性比格犬。
采用硫酸锌漂浮法（ZSCT）鉴定犬自然感染贾第虫属，将其分为3组。第1组犬每24小时口服吡喹酮（5.4至7毫克/千克体重）、双羟萘酸噻嘧啶（26.8至35.2毫克/千克）和非班太尔（26.8至35.2毫克/千克）联合用药，共给药3剂。第2组犬用药1次。第3组犬为未治疗的对照组。在最后一次治疗后6天内，对每组每只犬采集4份粪便样本，采用ZSCT进行检测。如果1份或更多粪便样本贾第虫囊肿检测呈阳性，则认为犬感染贾第虫病。在最后一次治疗后，每天对犬进行检查，至少检查10天。
第1组犬的粪便中未检测到贾第虫囊肿，第2组5只犬中有2只的粪便中未检测到囊肿。第3组（未治疗对照组）5只犬的粪便中均检测到囊肿。未观察到任何犬出现中毒迹象。
目前口服一次的联合用药标签剂量（用于治疗各种线虫和绦虫，但不包括贾第虫属）可减少感染贾第虫犬的囊肿排泄，对于排出贾第虫囊肿的犬，无论是否有感染的临床症状，都应考虑使用该药物进行治疗。
