Quandt J E, Robinson E P, Rivers W J, Raffe M R
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
Am J Vet Res. 1998 Sep;59(9):1137-43.
To compare cardiorespiratory and anesthesia effects of IV administered propofol and thiopental in dogs.
6 healthy mixed-breed dogs.
Each dog was anesthetized with isoflurane, then a thermistor catheter was inserted in the pulmonary artery. After a minimum of 2.5 hours of recovery, a catheter was placed in a cephalic vein for administration of lactated Ringer's solution and drugs. Propofol (8 mg/kg of body weight) or thiopental (19.4 mg/kg) was administered to each dog in a randomized crossover design study. All dogs were intubated and allowed to breathe 100% oxygen spontaneously. Heart rate and rhythm; systolic, diastolic, and mean arterial blood pressures; respiratory rate; end-tidal carbon dioxide concentration; tidal volume; and reflexes (toe web pinch, palpebral response, and jaw tone) were measured before and every 2 minutes for the first 10 minutes, then at 15, 30, and 60 minutes after drug administration. Cardiac output was determined at 0, 2, 6, 10, 15, 30, and 60 minutes, and blood samples were collected at 0, 2, 10, and 30 minutes. Time to endotracheal extubation, head lift, and ability to sit sternally and walk unaided were recorded.
3 of 6 dogs in each group were apneic after drug administration. Reflexes were decreased similarly for both anesthetic agents, but were not completely lost. Time to sternal position and walking unaided were significantly shorter in response to propofol.
Anesthesia was rapid; however, respiratory depression and apnea were major adverse effects associated with propofol and thiopental. Propofol has the advantage of inducing rapid, coordinated anesthesia recovery.
比较静脉注射丙泊酚和硫喷妥钠对犬的心肺及麻醉效果。
6只健康的杂种犬。
每只犬用异氟烷麻醉，然后将热敏电阻导管插入肺动脉。恢复至少2.5小时后，在头静脉放置一根导管用于输注乳酸林格氏液和药物。在一项随机交叉设计研究中，给每只犬注射丙泊酚（8毫克/千克体重）或硫喷妥钠（19.4毫克/千克）。所有犬均行气管插管，并允许自主呼吸100%氧气。在给药前及给药后的前10分钟每2分钟测量一次心率和心律、收缩压、舒张压和平均动脉血压、呼吸频率、呼气末二氧化碳浓度、潮气量以及反射（趾蹼捏压、眼睑反应和下颌张力），然后在给药后15、30和60分钟测量。在0、2、6、10、15、30和60分钟测定心输出量，并在0、2、10和30分钟采集血样。记录气管拔管时间、抬头时间以及自主坐立和行走的能力。
每组6只犬中有3只在给药后出现呼吸暂停。两种麻醉剂引起的反射减弱程度相似，但未完全消失。使用丙泊酚后，达到胸骨位和自主行走的时间明显缩短。
麻醉起效迅速；然而，呼吸抑制和呼吸暂停是丙泊酚和硫喷妥钠的主要不良反应。丙泊酚具有诱导麻醉快速、协调恢复的优势。
