Garcea N, Campo S, Marone M, Garcea R
Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
Gynecol Obstet Invest. 1998;46(3):214-6. doi: 10.1159/000010020.
The authors illustrate the case of a 17-year-old patient who was submitted to left adnexectomy in view of an ovarian dysgerminoma 24 cm in diameter and weighing 2,800 g. She was subsequently submitted to two cycles of radiotherapy. Following a period of amenorrhea lasting 13 years and characterized by high serum levels of gonadotropins, the patient had a spontaneous pregnancy and at 33 weeks of gestation delivered a live and vital fetus. Therefore the occurrence of post-radiotherapy amenorrhea, characterized by high serum gonadotropin levels, should not always be considered pathognomonic of precocious menopause. The possibility that radiotherapy causes only a temporary alteration in ovarian activity should also be taken into consideration.
作者阐述了一名17岁患者的病例，该患者因直径24厘米、重2800克的卵巢无性细胞瘤接受了左侧附件切除术。随后她接受了两个周期的放疗。在经历了持续13年的闭经，其特征为血清促性腺激素水平升高后，该患者自然受孕，并在妊娠33周时分娩出一个存活且健康的胎儿。因此，以血清促性腺激素水平升高为特征的放疗后闭经并不总是早熟绝经的特征性表现。还应考虑放疗仅导致卵巢活动暂时改变的可能性。
