• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

成瘾的合理治疗。

Rational treatment of addiction.

作者信息

Terenius L

机构信息

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

出版信息

Curr Opin Chem Biol. 1998 Aug;2(4):541-7. doi: 10.1016/s1367-5931(98)80132-4.

DOI:10.1016/s1367-5931(98)80132-4
PMID:9736929
Abstract

Treatment of alcohol and drug addictions, which has been neglected medically for a long time, is currently sparked with optimism. Craving for alcohol can be treated with two newly registered drugs: naltrexone and acamprosate. New approaches to symptom relief during detoxification or during maintenance therapies are rationally based on experimental and clinical work. It is now clear that addictive drugs are surrogates of natural substances involved in the 'reward system'.

摘要

长期以来在医学上被忽视的酒精和药物成瘾治疗，目前正充满乐观情绪。对酒精的渴望可用两种新注册的药物治疗：纳曲酮和阿坎酸。在戒毒或维持治疗期间缓解症状的新方法合理地基于实验和临床研究。现在很清楚，成瘾性药物是参与“奖励系统”的天然物质的替代品。

相似文献

1
Rational treatment of addiction.成瘾的合理治疗。
Curr Opin Chem Biol. 1998 Aug;2(4):541-7. doi: 10.1016/s1367-5931(98)80132-4.
2
Medications for substance use disorders.物质使用障碍的药物治疗。
Soc Work Public Health. 2013;28(3-4):264-78. doi: 10.1080/19371918.2013.759031.
3
Pharmacological treatments for substance use disorders.物质使用障碍的药物治疗。
J Psychosoc Nurs Ment Health Serv. 2004 Aug;42(8):14-20.
4
The integration of pharmacotherapy and nonpharmacotherapy.药物治疗与非药物治疗的整合。
J Addict Dis. 1997;16(4):51-64. doi: 10.1080/10550889709511143.
5
[The pharmacologic treatment of the alcohol dependence].[酒精依赖的药物治疗]
Braz J Psychiatry. 2004 May;26 Suppl 1:S43-6. doi: 10.1590/s1516-44462004000500011. Epub 2005 Jan 4.
6
[Depression in alcohol addicted patients].[酒精成瘾患者的抑郁症]
Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(7):146-150. doi: 10.17116/jnevro201511571146-150.
7
Pharmacologic approaches to the management of alcoholism.酒精中毒管理的药理学方法。
J Clin Psychiatry. 2001;62 Suppl 20:11-7.
8
[Drugs against alcohol abuse].[抗酒精滥用药物]
Tidsskr Nor Laegeforen. 2006 Dec 14;126(24):3268-9.
9
[Anesthetic considerations in a patient taking disulfiram and naltrexone for chronic alcoholism].
Rev Esp Anestesiol Reanim. 2011 Feb;58(2):128-9. doi: 10.1016/s0034-9356(11)70013-5.
10
Pharmacological treatment of alcohol dependence: a review of the evidence.酒精依赖的药物治疗：证据综述
JAMA. 1999 Apr 14;281(14):1318-25. doi: 10.1001/jama.281.14.1318.

引用本文的文献

1
Comparative Therapeutic Effects of Plant-Extract Synthesized and Traditionally Synthesized Gold Nanoparticles on Alcohol-Induced Inflammatory Activity in SH-SY5Y Cells In Vitro.植物提取物合成与传统合成的金纳米颗粒对体外培养的SH-SY5Y细胞酒精诱导炎症活性的比较治疗效果
Biomedicines. 2017 Dec 15;5(4):70. doi: 10.3390/biomedicines5040070.
2
Prodrug strategies for enhancing the percutaneous absorption of drugs.提高药物经皮吸收的前药策略。
Molecules. 2014 Dec 12;19(12):20780-807. doi: 10.3390/molecules191220780.
3
Preparation of mixed trialkyl alkylcarbonate derivatives of etidronic acid via an unusual route.
通过一条不寻常的路线制备混合三烷基碳酸二膦酸乙酯衍生物。
Beilstein J Org Chem. 2012;8:2019-24. doi: 10.3762/bjoc.8.228. Epub 2012 Nov 20.
4
Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery.纳曲酮的新型 3-O-聚乙二醇羧酸酯和 3-O-聚乙二醇碳酸酯前药用于微针增强经皮给药。
Bioorg Med Chem Lett. 2010 Jun 1;20(11):3280-3. doi: 10.1016/j.bmcl.2010.04.049. Epub 2010 Apr 18.
5
Human skin permeation of 3-O-alkyl carbamate prodrugs of naltrexone.纳曲酮 3-O- 烷基氨基甲酸酯前药的人体皮肤渗透。
J Pharm Sci. 2009 Aug;98(8):2611-25. doi: 10.1002/jps.21594.
6
Effects of naltrexone and acamprosate on alcohol-induced NGFI-A expression in mouse brain.
Neurochem Res. 2008 Oct;33(10):2062-9. doi: 10.1007/s11064-008-9687-8. Epub 2008 Apr 22.
7
In vitro/in vivo correlation of transdermal naltrexone prodrugs in hairless guinea pigs.无毛豚鼠中透皮纳曲酮前药的体外/体内相关性
Pharm Res. 2005 Jun;22(6):981-9. doi: 10.1007/s11095-005-4593-0. Epub 2005 Jun 8.
8
Human skin permeation of branched-chain 3-0-alkyl ester and carbonate prodrugs of naltrexone.纳曲酮的支链3 - O - 烷基酯和碳酸酯前药的人体皮肤渗透情况
Pharm Res. 2005 May;22(5):758-65. doi: 10.1007/s11095-005-2592-9. Epub 2005 May 17.
9
Physicochemical evaluation, in vitro human skin diffusion, and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone.纳曲酮3 - O - 烷基碳酸酯前药的物理化学评估、体外人体皮肤扩散及同步生物转化
Pharm Res. 2004 Jul;21(7):1146-52. doi: 10.1023/b:pham.0000033000.03652.73.