在妊娠期间用恩氟烷或甲氧氟烷麻醉的大鼠骨骼中的氟化物。

Fluoride in bone of rats anesthetized during gestation with enflurane or methoxyflurane.

作者信息

Fiserova-Bergerova V

出版信息

Anesthesiology. 1976 Nov;45(5):483-6.

Abstract

Fluoride concentrations in maternal and fetal bones were measured following exposure of pregnant rats to methoxyflurane and enflurane anesthesia. Fluoride content in fetal bone increased significantly only after exposure to methoxyflurane, and then only when methoxyflurane was administered after 12 days of gestation, when ossification of fetal bone begins. Fluoride concentrations in maternal bone increased following both anesthetics, except in rats exposed to methoxyflurane after 15 days of gestation, when ossification of many fetal skeletal parts is in progress and fluoride is preferentially deposited in the fetal skeleton.

摘要

在怀孕大鼠暴露于甲氧氟烷和恩氟烷麻醉后，测量母体和胎儿骨骼中的氟化物浓度。仅在暴露于甲氧氟烷后，胎儿骨骼中的氟含量才显著增加，而且只有在妊娠12天后给予甲氧氟烷时才会增加，此时胎儿骨骼开始骨化。两种麻醉剂都会使母体骨骼中的氟化物浓度升高，但在妊娠15天后暴露于甲氧氟烷的大鼠除外，此时许多胎儿骨骼部位正在进行骨化，氟化物优先沉积在胎儿骨骼中。