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[氟烷、恩氟烷和甲氧氟烷麻醉后呼出气体的气相色谱检查(作者译)]

[Gaschromatographic examination of the expired air after anaesthesia with halothane, enflurane and methoxyflurane (author's transl)].

作者信息

Klan P H, Herden H N, Lawin P

出版信息

Prakt Anaesth. 1975 Dec;10(6):356-60.

PMID:1233488
Abstract

The concentration of anaesthetic gases in the expired air was studied for up to 17 days in patients who had been anaesthetized with methoxyflurane, enflurane or halothane. The estimation were made by means of gaschromatography. The rate and duration of elimination of the anaesthetic via the lungs depends on the fat stores of the patient (as calculated by the body weight/stature ratio), the length of anaesthesia and the Lutz index (calculated average concentration of the inhaled anaesthetic). The concentration of anaesthetic gases in the expired air fell steeply during the first 12 hours after anaesthetic and then decreased more gradually. The drop in concentration during the first 24 hours was steepest for methoxyflurane, followed by halothane and enflurane in that order. The results are in fair agreement with the rate of metabolization of the three anaesthetic agents. The investigation showed that during the first after anaesthesia appreciable quantities of anaesthetic gases are eliminated via the lungs and, consequently, released into the air of the recovery room.

摘要

对接受甲氧氟烷、恩氟烷或氟烷麻醉的患者,研究其呼出气体中麻醉气体的浓度长达17天。采用气相色谱法进行测定。麻醉剂经肺排出的速率和持续时间取决于患者的脂肪储备(通过体重/身高比计算)、麻醉时间和卢茨指数(吸入麻醉剂的计算平均浓度)。麻醉后最初12小时内,呼出气体中麻醉气体的浓度急剧下降,随后下降更为缓慢。在最初24小时内,甲氧氟烷的浓度下降最为陡峭,其次是氟烷和恩氟烷,顺序依次如此。结果与三种麻醉剂的代谢速率相当一致。调查显示,麻醉后的最初阶段,相当数量的麻醉气体经肺排出,因此释放到恢复室的空气中。

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