Pusuwan P, Likitmaskul S, Wacharasindhu S, Intarasupht S, Attanatho V, Mungkharak J, Chiewvit S, Pleehachinda R
Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 1998 Aug;81(8):596-601.
The presence or absence of thyroid glandular tissue demonstrated by thyroid scintigraphy is important for genetic and prognostic counseling and for acceleration of diagnosis in other affected siblings. Technetium-99m-pertechnetate thyroid scintigraphy was performed on 27 children with cretinism at the Division of Nuclear Medicine, Faculty of Medicine Siriraj Hospital during the 5-year period from June 1991. Based on scintigraphic findings, three main groups of thyroid localization were seen. Thirteen (48.1%) were athyrotic while 3 (11.1%) had an ectopic thyroid and 11 (40.8%) had gland in normal position. Perchlorate discharge test was performed in 8 children of the last group and the results were positive indicating an organification defect. Thyroid scintigraphy and perchlorate discharge test provided the useful information for diagnosis, follow-up, and prognosis in children with cretinism.
甲状腺闪烁扫描显示的甲状腺腺组织的有无对于遗传和预后咨询以及加速其他受影响同胞的诊断很重要。1991年6月至1996年6月的5年期间，在诗里拉吉医院医学院核医学科对27例克汀病患儿进行了锝-99m高锝酸盐甲状腺闪烁扫描。根据闪烁扫描结果，可见三种主要的甲状腺定位类型。13例（48.1%）为无甲状腺，3例（11.1%）有异位甲状腺，11例（40.8%）甲状腺位置正常。对最后一组中的8名儿童进行了高氯酸盐释放试验，结果呈阳性，表明存在有机化缺陷。甲状腺闪烁扫描和高氯酸盐释放试验为克汀病患儿的诊断、随访和预后提供了有用信息。
