Sinsawaiwong S, Phanthumchinda K
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1998 Sep;81(9):717-21.
A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities. The thigh and buttock muscles were "wooden-hard" on palpation. The skin was hard, shiny and hairless. Associated clinical and electrophysiological polyradiculopathy and multiple mononeuropathy of the lower extremities were observed. Imaging studies showed calcification and fibrosis of the involved muscles. Muscle biopsy revealed fibrous myopathy. Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.
一名47岁女性，有4年下肢肌肉注射喷他佐辛的病史，逐渐出现下肢僵硬和无力。触诊时大腿和臀部肌肉“硬如木板”。皮肤坚硬、发亮且无毛发。观察到伴有临床和电生理多神经根病以及下肢多发性单神经病。影像学研究显示受累肌肉有钙化和纤维化。肌肉活检显示为纤维性肌病。为防止不可逆的药物性纤维性肌病和局限性神经病，谨慎长期使用并早期识别喷他佐辛毒性作为一种神经肌肉并发症很重要。
