Gao P S, Mao X Q, Kawai M, Enomoto T, Sasaki S, Tanabe O, Yoshimura K, Shaldon S R, Dake Y, Kitano H, Coull P, Shirakawa T, Hopkin J M
Osler Chest Unit, Churchill Hospital, Oxford, UK.
Hum Genet. 1998 Jul;103(1):57-9. doi: 10.1007/s004390050783.
The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 1lq13. A genetic association study was performed with variants of the CC16 gene on chromosome 1lq13 in relation to asthma in British (n=275) and Japanese (n=300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.
编码克拉拉细胞衍生炎症分子CC16的基因已被认为是11号染色体长臂13区特应性哮喘的候选基因。对英国人群（n = 275）和日本人群（n = 300）中11号染色体长臂13区CC16基因变体与哮喘进行了基因关联研究。在这两个人群中，无论特应状态如何，哮喘与CC16基因型之间均未发现显著关联。这些数据表明，CC16可能不是11q13上哮喘的主要基因座。
