Rochiccioli P, Enjeaume P, Dutau G, Ribot C, Augier D
Arch Fr Pediatr. 1976 May;33(5):453-65.
Two tests of stimulation: insulin + arginine and propranolol + glucagon were successively performed in 62 children who were either normal or had essential growth retardation. Average peak value was 10.6 +/- 1.1 ng/ml in the first test and 22.8 +/- 1.4 ng/ml in the second. In 56 cases the response obtained with propranolol + glucagon was higher than that obtained with insulin + arginine. Twenty-four false negative results were obtained employing insulin + arginine, stimulation by propranolol + glucagon resulting in normal values. The determination of the confidence interval at 95% and of the 3rd percentile did not allow to establish the lower threshold for the insulin + arginine test. For the propranolol + glucagon test 7.6 ng/ml for the interval at 95% and 8 ng/ml for 3rd percentile were found as minimal threshold. Therefore, a response below 8 ng/ml should be considered as pathological with the latter test.
对62名正常或患有原发性生长发育迟缓的儿童先后进行了两项刺激试验：胰岛素+精氨酸试验和普萘洛尔+胰高血糖素试验。第一次试验的平均峰值为10.6±1.1 ng/ml，第二次试验为22.8±1.4 ng/ml。在56例中，普萘洛尔+胰高血糖素试验获得的反应高于胰岛素+精氨酸试验。使用胰岛素+精氨酸试验时出现了24例假阴性结果，而普萘洛尔+胰高血糖素刺激试验结果正常。95%置信区间和第3百分位数的测定无法确定胰岛素+精氨酸试验的下限阈值。对于普萘洛尔+胰高血糖素试验，95%区间的最低阈值为7.6 ng/ml，第3百分位数为8 ng/ml。因此，后一项试验中低于8 ng/ml的反应应被视为病理性反应。
