Le Pogam S, Le Chapois D, Christen R, Dubois F, Barin F, Goudeau A
Département de Microbiologie Médicale et Moléculaire, CHU Bretonneau, 37044 Tours Cedex, France.
J Clin Microbiol. 1998 Oct;36(10):3040-3. doi: 10.1128/JCM.36.10.3040-3043.1998.
This study reports four cases of transmission of the rare hepatitis C virus genotype 4 which occurred in a hemodialysis unit and originated from a single source of infection. Phylogenetic analyses performed with the NS5b domain showed that all four patients with secondary infections were infected with virus strains very similar to that of the index patient. Cross infections probably resulted from breaches in safety precautions and lack of dialysis machine sterilization.
本研究报告了4例罕见的丙型肝炎病毒4型传播病例，这些病例发生在一个血液透析单元，且源于单一传染源。对NS5b结构域进行的系统发育分析表明，所有4例继发感染患者均感染了与首例患者病毒株非常相似的病毒。交叉感染可能是由于安全预防措施存在漏洞以及透析机未进行消毒所致。
