反式-2,3b,4,5,7,8b,9,10-八氢萘并[1,2-c:5,6-c']二吡唑，一种新型口服活性抗过敏化合物。
trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound.
作者信息
Vítolo M J, Márquez V E, Hurtado I
出版信息
J Med Chem. 1978 Jul;21(7):692-4. doi: 10.1021/jm00205a020.
PMID:97384
Abstract
The synthesis and antiallergic activity of a new heterocyclid steroidal molecule are described. Compound 1 was shown to inhibit the rat passive cutaneous anaphylaxis and its activity in this system was compared to that of disodium cromoglycate. It is orally active at a dose of 35 mg/kg (ED50) and its activity persists for up to 6 h for larger doses.
摘要
描述了一种新型杂环甾体分子的合成及其抗过敏活性。化合物1被证明能抑制大鼠被动皮肤过敏反应，并将其在该系统中的活性与色甘酸钠的活性进行了比较。它在35mg/kg（半数有效剂量）的剂量下具有口服活性，对于更大剂量，其活性可持续长达6小时。
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