Kuo T, Speyer M T, Ries W R, Reinisch L
Department of Otolaryngology, Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2559, USA.
Lasers Surg Med. 1998;23(2):66-71. doi: 10.1002/(sici)1096-9101(1998)23:2<66::aid-lsm3>3.0.co;2-t.
Objectively measure and compare postoperative collagen thermal damage and subsequent new collagen synthesis after cutaneous laser resurfacing using two carbon dioxide laser systems.
STUDY DESIGN/MATERIALS AND METHODS: We created 240 resurfacing wounds on eight piglets with scanned and short-pulsed lasers using the manufacturer's suggested settings. The wounds varied with respect to the number of laser passes and postoperative survival times. Samples were harvested for histological analysis.
The scanned laser resulted in an average of 52% more collagen thermal damage on the day of surgery (P < 0.0001) and an average of 78% more thermal damage 3 days postoperative (P < 0.0001) than the short-pulsed laser. The amount of new collagen synthesis correlated with the amount of thermal damage, with the scanned laser wounds showing 44% greater new collagen synthesis than the short-pulsed laser wounds on postoperative day 7 (P < 0.0001) and 48% greater new collagen synthesis on postoperative day 14 (P < 0.0001).
Compared to the short-pulsed laser, the scanned laser results in a greater depth of collagen thermal damage with a correspondingly greater depth of new collagen synthesis after cutaneous resurfacing.
使用两种二氧化碳激光系统客观测量并比较皮肤激光换肤术后的胶原热损伤及随后的新胶原合成情况。
研究设计/材料与方法：我们使用制造商建议的设置，用扫描激光和短脉冲激光在八只小猪身上制造了240个换肤伤口。伤口在激光照射次数和术后存活时间方面有所不同。采集样本进行组织学分析。
与短脉冲激光相比，扫描激光在手术当天造成的胶原热损伤平均多52%（P < 0.0001），术后3天的热损伤平均多78%（P < 0.0001）。新胶原合成量与热损伤量相关，在术后第7天，扫描激光伤口的新胶原合成比短脉冲激光伤口多44%（P < 0.0001），术后第14天多48%（P < 0.0001）。
与短脉冲激光相比，扫描激光在皮肤换肤后造成的胶原热损伤更深，相应地新胶原合成深度也更大。
