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铒:钇铝石榴石激光小梁切除术(LTA)在青光眼手术治疗中的应用。

Erbium: YAG laser trabecular ablation (LTA) in the surgical treatment of glaucoma.

作者信息

Dietlein T S, Jacobi P C, Krieglstein G K

机构信息

Department of Ophthalmology, University of Cologne, Germany.

出版信息

Lasers Surg Med. 1998;23(2):104-10. doi: 10.1002/(sici)1096-9101(1998)23:2<104::aid-lsm8>3.0.co;2-t.

Abstract

BACKGROUND AND OBJECTIVE

Laser trabecular ablation (LTA) aims to remove trabecular tissue and to open Schlemm's canal in order to improve outflow facility in glaucomatous eyes. The purpose of our study was to investigate the pressure-reducing effect of LTA in chronic open-angle glaucoma 1 year following laser surgery.

STUDY DESIGN/MATERIALS AND METHODS: Eleven eyes of 11 patients with chronic open-angle glaucoma were treated by circumscribed laser ablation of the trabecular meshwork. We used an Erbium:YAG laser (2.94 microm) with a quartz fiber contact endoprobe (320 microm core-diameter, 385 microm coating-diameter) applying 11-30 single neighbouring laser pulses (5-7 mJ) to the trabecular meshwork by an ab-interno approach. Laser procedure was gonioscopically visualized.

RESULTS

Mean maximum intraocular pressure (IOP) of all 11 patients before LTA was 36 mmHg and dropped down to 22 mmHg after a mean follow-up of 12 months following LTA; this represents an IOP decrease of 38% (P=0.008). The average number of medications per eye dropped from 2.8 to 1.5 per eye (P=0.021).

CONCLUSION

Although IOP lowering effect of Erbium:YAG laser trabecular ablation did not prove as effective as in filtering procedures, LTA might be a valuable alternative in glaucoma surgery especially in order to avoid conjunctival scarring and postoperative hypotony.

摘要

背景与目的

激光小梁消融术(LTA)旨在去除小梁组织并开放施莱姆管,以改善青光眼患者的房水流出功能。本研究的目的是调查激光手术后1年LTA对慢性开角型青光眼的降压效果。

研究设计/材料与方法:对11例慢性开角型青光眼患者的11只眼进行小梁网局限性激光消融治疗。我们使用掺铒钇铝石榴石激光(波长2.94微米),通过石英纤维接触式内探头(芯径320微米,涂层直径385微米),经内路法向小梁网施加11 - 30个相邻的单次激光脉冲(能量5 - 7毫焦)。激光操作在房角镜下进行可视化观察。

结果

所有11例患者在LTA术前的平均最高眼压为36 mmHg,LTA术后平均随访12个月后降至22 mmHg;眼压降低了38%(P = 0.008)。每只眼的平均用药数量从2.8种降至1.5种(P = 0.021)。

结论

尽管掺铒钇铝石榴石激光小梁消融术的降眼压效果不如滤过手术显著,但LTA可能是青光眼手术中一种有价值的替代方法,特别是为了避免结膜瘢痕形成和术后低眼压。

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