Stoler J M, Huntington K S, Peterson C M, Peterson K P, Daniel P, Aboagye K K, Lieberman E, Ryan L, Holmes L B
Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston 02114, USA.
J Pediatr. 1998 Sep;133(3):346-52. doi: 10.1016/s0022-3476(98)70267-7.
To examine the efficacy of a combination of 4 blood markers of alcohol use in detecting alcohol-abusing pregnant women.
Two new markers of alcohol use, whole blood-associated acetaldehyde and carbohydrate-deficient transferrin, and 2 traditional markers of alcohol use, gamma-glutamyl transpeptidase and mean red blood cell volume, were measured in the blood of pregnant women. Each woman was interviewed about alcohol and drug use, medical and obstetric histories, and nutrition. Each infant was examined by a clinician who was blinded to exposure status.
All of the women who reported drinking an average of 1 or more ounces of absolute alcohol per day had at least 1 positive blood marker. The infants of mothers with 2 or more positive markers had significantly smaller birth weights, lengths, and head circumferences than the infants with negative maternal screens. The presence of 2 or more positive markers was more predictive of infant outcome than any self-reporting measure.
These markers, which detect more at-risk pregnant women than self-reporting methods, could lead to better efforts at detection and prevention of alcohol-induced fetal damage.
研究4种酒精使用血液标志物联合检测对酗酒孕妇的诊断效能。
检测孕妇血液中两种新的酒精使用标志物——全血相关乙醛和缺糖转铁蛋白，以及两种传统的酒精使用标志物——γ-谷氨酰转肽酶和平均红细胞体积。每位孕妇均接受关于酒精和药物使用、医疗及产科病史以及营养状况的访谈。每位婴儿由对暴露状态不知情的临床医生进行检查。
所有报告平均每天饮用1盎司或更多纯酒精的女性，血液标志物至少有一项呈阳性。有两项或更多阳性标志物的母亲所生婴儿的出生体重、身长和头围明显低于母亲筛查为阴性的婴儿。两项或更多阳性标志物的存在比任何自我报告指标更能预测婴儿结局。
这些标志物比自我报告方法能检测出更多高危孕妇，有助于更好地检测和预防酒精所致胎儿损伤。
