London S D, Park S S, Gampper T J, Hoard M A
Department of Otolaryngology-Head and Neck Surgery, University of Virginia Medical Center, Charlottesville 22906-0008, USA.
Laryngoscope. 1998 Sep;108(9):1291-6. doi: 10.1097/00005537-199809000-00005.
To review the use of hyperbaric oxygen in the management of radionecrosis of the head and neck.
A retrospective analysis of patients utilizing chart review and telephone interviews. All patients diagnosed with osteoradionecrosis and chondroradionecrosis of the head and neck and treated with hyperbaric oxygen at the University of Virginia are included.
Demographics, pretreatment data, and precipitating events were recorded. Outcomes were evaluated using a grading scale of symptomatology and physical examination as determined by the patient and physician.
Sixteen patients with osteoradionecrosis and five with chondroradionecrosis were reviewed. All patients showed clinical improvement with decreased pain following HBO therapy. None of the patients with chondroradionecrosis required laryngectomies, and two of the four who were tracheotomy dependent were successfully decannulated. The patient and physician grading scores demonstrated moderate to significant improvement in both groups following therapy.
The successful use of hyperbaric oxygen for the management of radionecrosis of the head and neck is supported. The unusual prevalence of chondroradionecrosis may be an early reflection of changes in treatment protocols for patients with head and neck cancer.
回顾高压氧在头颈部放射性坏死治疗中的应用。
通过病历回顾和电话访谈对患者进行回顾性分析。纳入所有在弗吉尼亚大学被诊断为头颈部骨放射性坏死和软骨放射性坏死并接受高压氧治疗的患者。
记录人口统计学资料、治疗前数据和诱发事件。采用由患者和医生确定的症状和体格检查分级量表评估结果。
对16例骨放射性坏死患者和5例软骨放射性坏死患者进行了回顾。所有患者在高压氧治疗后疼痛减轻,临床症状改善。软骨放射性坏死患者均无需行喉切除术,4例依赖气管切开术的患者中有2例成功拔管。治疗后两组患者和医生的分级评分均有中度至显著改善。
支持高压氧成功用于头颈部放射性坏死的治疗。软骨放射性坏死的异常高发性可能是头颈癌患者治疗方案变化的早期反映。