Manders S M
Department of Medicine, University of Medicine and Dentistry of New Jersey--Robert Wood Johnson Medical School at Camden, USA.
J Am Acad Dermatol. 1998 Sep;39(3):383-98; quiz 399-400. doi: 10.1016/s0190-9622(98)70314-7.
After several decades of seemingly decreasing virulence, streptococcal and staphylococcal infections have reemerged as a major source of morbidity and mortality. Within the past 2 decades, not only have well-established diseases such as rheumatic fever begun to reappear. but also many new entities, such as toxic shock syndrome, streptococcal toxic shock syndrome, recurrent toxin-mediated perineal erythema, and recalcitrant erythematous desquamating disorder have been described. Central to the renewed importance of these bacteria has been the production of circulating toxins, which often function as superantigens in causing the clinical manifestations, morbidity and mortality associated with these diseases.
在经历了几十年毒力看似下降的情况后，链球菌和葡萄球菌感染再度成为发病和死亡的主要原因。在过去20年里，不仅诸如风湿热等早已存在的疾病开始再度出现，而且还描述了许多新病症，如中毒性休克综合征、链球菌中毒性休克综合征、复发性毒素介导的会阴部红斑以及顽固性红斑脱屑性疾病。这些细菌重新变得重要的核心在于循环毒素的产生，这些毒素在引发与这些疾病相关的临床表现、发病率和死亡率方面常常作为超抗原发挥作用。
