Davies M J, Woolf N, Robertson W B
Br Heart J. 1976 Jul;38(7):659-64. doi: 10.1136/hrt.38.7.659.
Analysis of the pathological findings in 500 cases of fatal acute myocardial infarction showed that in 469 this was localized to one transmural area of the left ventricle; in 31 there was diffuse subendocardial necrosis. In the former occlusive coronary thrombus was found in the related artery in 95 per cent of cases. Variation in the percentage of occlusions found was noted between different prosectors and when coronary artery calcification was present. Only 4 of the 31 patients with subendocardial necrosis had recent occlusion; triple vessel disease was common in this group suggesting general failure of coronary perfusion. It is essential in necropsy studies of the relation of coronary thrombosis to myocardial infarction to be sure that muscle necrosis is present, to distinguish the two forms of myocardial necrosis, and to employ a meticulous dissection technique with decalcification of the arteries when necessary.
对500例致命性急性心肌梗死病例的病理结果分析显示，其中469例梗死局限于左心室的一个透壁区域；31例有弥漫性心内膜下坏死。在前者中，95%的病例在相关动脉中发现闭塞性冠状动脉血栓。不同病理学家之间以及存在冠状动脉钙化时，发现的闭塞百分比存在差异。31例心内膜下坏死患者中只有4例近期有闭塞；该组中三支血管病变常见，提示冠状动脉灌注普遍衰竭。在关于冠状动脉血栓形成与心肌梗死关系的尸检研究中，必须确保存在肌肉坏死，区分两种心肌坏死形式，并在必要时采用细致的解剖技术并对动脉进行脱钙处理。
