地西泮在急性心肌梗死中的应用。对儿茶酚胺、游离脂肪酸和皮质醇的临床效应及影响
Diazepam in acute myocardial infarction. Clinical effects and effects on catecholamines, free fatty acids, and cortisol.
作者信息
Melsom M, Andreassen P, Melsom H, Hansen T, Grendahl H, Hillestad L K
出版信息
Br Heart J. 1976 Aug;38(8):804-10. doi: 10.1136/hrt.38.8.804.
Diazepam is a valuable drug in cases of acute myocardial infarction. The 10 mg intravenous loading dose and the subsequent 15 mg oral dose of diazepam administered three times daily produced safe, pleasant sedation, and reduced the need for analgesics. A much reduced excretion of catecholamines was recorded. It is presumed that diazepam causes a lower stress reaction, which is beneficial in diminishing the incidence of malignant arrhythmias and preventing the existing myocardial injury from spreading.
地西泮在急性心肌梗死病例中是一种有价值的药物。静脉注射10毫克地西泮负荷剂量，随后每日三次口服15毫克地西泮，可产生安全、舒适的镇静效果，并减少了对镇痛药的需求。记录显示儿茶酚胺的排泄量大幅减少。据推测，地西泮可降低应激反应，这有利于减少恶性心律失常的发生率，并防止现有的心肌损伤扩散。
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