Inagaki T, Ebisuno S
Minami Wakayama National Hospital Division of Urology.
Nihon Hinyokika Gakkai Zasshi. 1998 Jul;89(7):674-7. doi: 10.5980/jpnjurol1989.89.674.
We present a case of asynchronous development of transitional cell carcinoma in urinary bladder and renal pelvis after prolonged cyclophosphamide therapy. A 57-year-old woman had received 290 g cyclophosphamide for 13 years because of therapy for non-Hodgkin lymphoma. She was suffered from dysuria and macrohematuria and visited our clinic. Cystoscopy, CT and MRI revealed invasive bladder tumor and total cystectomy was performed. Histological diagnosis was transitional cell carcinoma, G3 < G2, pT4. Six months after the cystectomy, a follow up urography and computerized tomography showed left renal pelvic tumor. The patient underwent total nephroureterectomy, and the histological diagnosis was transitional cell carcinoma, G3, pT3. We reviewed cyclophosphamide induced urothelial carcinomas from Japanese and world literatures.
我们报告一例长期使用环磷酰胺治疗后膀胱和肾盂移行细胞癌异步发生的病例。一名57岁女性因非霍奇金淋巴瘤接受治疗，13年间共接受了290克环磷酰胺治疗。她出现排尿困难和肉眼血尿后来我院就诊。膀胱镜检查、CT和MRI显示为浸润性膀胱肿瘤，遂行全膀胱切除术。组织学诊断为移行细胞癌，G3＜G2，pT4。膀胱切除术后6个月，随访尿路造影和计算机断层扫描显示左肾盂肿瘤。患者接受了全肾输尿管切除术，组织学诊断为移行细胞癌，G3，pT3。我们回顾了来自日本和世界文献中有关环磷酰胺诱导的尿路上皮癌的情况。
