Rapp L, Chen J J
Department of Dermatology, New England Medical Center, Boston, MA, USA.
Biochim Biophys Acta. 1998 Aug 19;1378(1):F1-19. doi: 10.1016/s0304-419x(98)00009-2.
Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.
特定类型的人乳头瘤病毒（HPV）与宫颈癌的发生密切相关。来自与癌症相关的HPV的E6基因在肿瘤发生、转录调控、端粒酶和细胞凋亡方面已表现出功能。与癌症相关的HPV E6蛋白结合肿瘤抑制因子p53，并通过泛素依赖性途径促进其降解。最近还发现了几种额外的细胞E6结合蛋白，并认为它们在E6的不依赖p53的功能中发挥作用。
